UPTAKE OF 6-FLUORO-5-HYDROXYTRYPTAMINE AND 4,6-DIFLUORO-5-HYDROXYTRYPTAMINE INTO RELEASABLE AND NON-RELEASABLE COMPARTMENTS OF HUMAN PLATELETS
نویسندگان
چکیده
منابع مشابه
5- Hydroxytryptamine
eral kinetic systems and compares their properties (after cautioning the reader of the possible pitfalls and of the assumptions which must be made) with various biological phenomena such as regulation, regeneration, determination , gene action, pleiotropism, etc. Few biologists have been as successful as Waddington in accomplishing a synthesis between embryology and genetics. In this volume, he...
متن کاملFactors affecting the uptake of 5-hydroxytryptamine by human platelets in an inorganic medium.
Since the original observations on the presence of 5-hydroxytryptamine (serotonin) in blood platelets there have been many reports on the ability of these blood elements to take up this amine (l-10). The early studies of Zucker and Borelli (3), Humphrey and Toh (1) and Hardistey and Stacey (2) clearly showed that the uptake of 5-hydroxytryptamine by platelets resulted in greater concentrations ...
متن کاملHistochemical demonstration of 5-hydroxytryptamine in platelets and megakaryocytes.
I_IAND AND REID 1 were the first to show that circulating 5-hydroxytryptamine ( 5-HT) is concentrated in the blood platelets. Under normal conditions, there is no detectable 5-HT in the circulating blood components other than platelets. Clark et al.2 and Gaddum and Giarman3 showed that both spleen and bone marrow are lacking the enzyme, 5-hydroxytryptophan (5HiP) decarboxylase, and that a large...
متن کاملEffects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.
Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascula...
متن کاملNeuropharmacology of 5-hydroxytryptamine.
This review outlines the history of our knowledge of the neuropharmacology of 5-hydroxytryptamine (5-HT; serotonin), focusing primarily on the work of U.K. scientists. The existence of a vasoconstrictive substance in the blood has been known for over 135 years. The substance was named serotonin and finally identified as 5-HT in 1949. The presence of 5-HT in the brain was reported by Gaddum in 1...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1982
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1982.tb08778.x